JaCVAM Activities

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Update on JaCVAM(updated on Oct.23 , 2014 )

:completion :On going :Reservation or Reservation :to be started
Classification Test name
(Formal names are shown by mouse over.)
Validation study Peer reviews by experts Test guidelines Regulatory
acceptance by,
e.g., JaCVAM
Regulatory
acceptance board
Recommendation
to
government
Collaboration
01Corrosivity test 01Vitrolife-skin

Reconstructed human tissue (developed in Japan; Vitrolife-Skin) cytotoxicity assay

NIHS
JaCVAM
 
2008.6
2008.8
MHLW
JSAAE
02Phototoxicity 013T3-NRU

In Vitro 3T3 NRU (neutral red uptake)Phototoxicity Test

COLIPA/ECVAM
NIHS
OECD TG
No.432

 
 
MHLW
JSAAE
02Yeast-RBC assay/span>

Combination of yeast growth and hemolysis testing as alternative phototoxicity test

NIHS
JaCVAM
 
2010.1
Reservation
MHLW
JSAAE
01ROS

ROS (reactive oxygen species) assay

NIHS
JaCVAM
ICH
S10

On going
 
MHLW
JPMA
03Skin sensitization test 01LLNA

Local lymph node assay (LLNA)

Not done
ICCVAM
OECD TG
N0.429

 
 
ICCVAM
ECVAM
02rLLNA

Reduced LLNA (rLLNA)

ECVAM &
ICCVAM
ICCVAM
OECD TG
N0.429

2012.7
2012.12
ICCVAM
ECVAM
JaCVAM
03LLNA:DA

LLNA:DA (LLNA modified by Daicel based on ATP content)

NIHS
JaCVAM or
ICCVAM
OECD TG
N0.442A

2012.10
2012.12
MHLW
JSAAE
04LLNA:BrdU-ELISA

LLNA:BrdU-ELISA

NIHS
JaCVAM or
ICCVAM
OECD TG
N0.442B

2012.10
2012.12
MHLW
JSAAE
05h-CLAT

Human cell line activation test (h-CLAT) for alternative skin sensitization assay

NIHS &
ECVAM
ESAC
Draft TG
On going
 
MHLW
ECVAM
06DPRA

Direct peptide reactivity assay (DPRA) for alternative skin sensitization assay

ECVAM
ESAC
Draft TG
On going
 
ECVAM
07KeratinoSense

KeratinoSense assay for alternative skin sensitization assay

ECVAM
ESAC
Draft TG
On going
 
ECVAM
08IL-8 Luc assay

IL-8 Luc assay for alternative skin sensitization assay

METI
 
 
 
 
ICATM
04Skin irritation 01LabCyte EPI-MODEL24

Alternative skin irritation test method using Reconstructed human tissue (developed in Japan; LabCyte EPI-MODEL)

NIHS
OECD
OECD TG
N0.439

2013.6
2013.12
MHLW
JSAAE
02Episkin, EpiDerm, SkinEthic

alternative skin irritation test method using Reconstructed human tissue (Episkin, EpiDerm, SkinEthic)

ECVAM
ESAC
OECD TG
N0.439

2013.3
2013.3
ECVAM
05Skin absorption test 01In vitro

In vitro

 
OECD
OECD TG
N0.428

2013.10
2014.1
 
06Ocular irritation test 01BCOP

Bovine corneal opacity and permeability (BCOP) test method

ECVAM &
ICCVAM
ECVAM &
ICCVAM
OECD TG
N0.437

2013.10
2014.1
ICCVAM
02ICE

Isolated chicken eye (ICE) test method

ECVAM &
ICCVAM
ECVAM &
ICCVAM
OECD TG
N0.438

2009.  On going
  
2009.12
ECVAM
03FL

Fluorescein Leakage Test Method

ECVAM &
ICCVAM
ESAC
OECD TG
N0.460

2012.10
2012.12
ECVAM
04CM

Cytosensor microphysiometer test

ECVAM
ESAC
Draft TG
On going
 
ECVAM
05STE

Cytotoxicity test: short time exposure (STE) test

NIHS
ICCVAM
Draft TG
On going
 
MHLW
JSAAE
06SIRC-CVS

Cytyotoxicity test: the rabbit cornea-derived cell line (SIRC-CVS) assay

NIHS
 
 
 
 
MHLW
ICATM
07MATREX

Cytyotoxicity test: Reconstructed human tissue (developed in Japan; MATREX)

Reservation
 
 
 
 
 
08EpiOcular

Reconstructed coreal tissue assay (EpiOcular)

COLIPA / ECVAM
ESAC
Draft TG
On going
 
ECVAM
09Vitrigel-EIT

Collagen gel (Vitrigel)-eye irritation test (EIT)

MAFF
 
 
 
 
MAFF
ICATM
10OECD TG
No.405 (2012)

Eye irritation assay using anesthetics

Not done
ICCVAM review
OECD TG
N0.405

2013.10
2014.1
ICCVAM
07Genotoxicity test 01in vitro

In vitro mammalian cell micronucleus test (chromosome abnormality test)

 
 
OECD
TG NO.473
TG NO.487
On going
 
JEMS
02in vitro comet assay

In vitro comet assay

NIHS
 
 
 
 
MHLW / JEMS / MMS
ICCVAM / ECVAM
03in vivo comet assay

In vivo comet assay

NIHS
OECD
OECD TG
No.489

 
 
MHLW / JEMS / MMS
ICCVAM / ECVAM
04EpiDerm

Micronucleus test using reconstructed epidermal model

COLIPA / ECVAM
 
 
 
 
ECVAM
08Acute oral toxicity test 01Cytotoxicity test

Cytotoxicity tests to estimate starting doses for acute oral systemic toxicity tests

ECVAM &
ICCVAM
ICCVAM
OECD GD
N0.129

2011.4
2011.6
ICCVAM
ECVAM
09Endcrine disrupter screening 01ER-STTA (agonist)

Estrogen receptor-stably transfected transactivation assay (ER-STTA) for the screening of agonistic activitiy of chemicals

METI
OECD
OECD TG
N0.455

 
 
MHLW
METI
02ER-STTA (antagonist)

ER-STTA for the screening of anti-agonistic activity of chemicals

METI & MHLW
 
Draft TG
On going
 
MHLW
METI
KFDA
03BG1Luc ERTA

BG1Luc estrogen receptor transactivation assay (ERTA) for the screeing of agonistic and anti-agonistic activity of chemicals

ICCVAM
ICCVAM
OECD TG
N0.457

2013.10
2014.1
MHLW / ICCVAM
ECVAM / JaCVAM
04CCi

CCi MCF-7 assay for the screening of estrogenic and anti-estrogenic activity of chemicals

ICCVAM
Canceld
 
 
 
ICCVAM
KoCVAM
JaCVAM
05MELN

MELN (derived from MCF-7) cell assay for the screening of estrgenic and anti-estrogenic activity of chemicals

ECVAM
 
 
 
 
ECVAM
06AR-Ecoscreen

AR-EcoScreen (the cell line expressing androgen receptor) assay for the screening of androgenic activity of chemicals

METI
 
 
 
 
METI
10Embryonic toxicoty scrneeing 01Hand1-Luc

Hand1-Luc Embryonic Stem Cell Test (Hand1-Luc EST)

METI
 
 
 
 
NEDO
METI
ICATM
11Metabolism 01CYP induction method

Cytochrome P-450 induction based metabolic-competent model system

ECVAM
ESAC
Draft TG
On going
 
ECVAM
12Cell transformation assay for the screening of carcinogenitic activity of chemicals 01Bhas

Bhas 42 cell transformation assay

NEDO
ESAC
Draft TG
On going
 
NEDO
METI
02 SHE

Syrian hamster embryo (SHE) cell transformation assay

ECVAM
ESAC
Draft TG
On going
 
ECVAM
03Balb

BALB/c 3T3 cell transformation assay

ECVAM
ESAC
Reservation
 
 
ECVAM
13Pyrogen screening test 01In vitro PBMC

in vitro pyrogen test method

ECVAM
ECVAM &
ICCVAM
Ph.Eur.
2010.12
Reservation
ECVAM
ICCVAM
All abbreviations that have been used in this table are listed in "Abbreviations". PDFでプリントアウトする

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